Here is a powerpoint file ending with me scratching her ear and her paw on my hand. Explore a new concept of communication with lots of ways of expressing yourself. Pharmacokinetics pk is the study of the time course of the absorption, distribution, metabolism and excretion adme of a drug, compound or new chemical entity nce after its administration to. The presentation will be available on paho website in 48 horas at. Powerpoint provides a quick view of your recent files for easy access on any device. The microsoft directx enduser runtime provides updates to 9. The backgrounds in this category contains images and illustrations that can be used as metaphors to produce high quality winning presentations, podium slide designs or. Pharmacodynamic models describe how a drug affects the body by linking the drug concentration to an efficacy or safety metric. This speedometer has been created in excel with help of autoshapes. Creating a pecha kucha presentation using powerpoint. The animated pdca powerpoint template contains a range of animated diagram layouts for you to create your deming cycle. Pharmacokinetic and pharmacodynamic modeling of an anti. Microsoft powerpoint real program powerpoint microsoft for phones and tablets android. Applications of software packages in pharmacokinetics applied.
Allows users to create, edit and save presentations. Need to access your most recently used powerpoint files quickly while on the go. Take on challenges to earn coins and customize your avatar and home. Although some of the concepts associated with pharmacokinetics are much older eg, michaelismenten equation in 19, hill equation in 1908, the study of pharmacokinetics and pharmacodynamics pd has only been popularized over the last 60 years. Statisticians deal with groups, not individual people or patients. The improvements in computing have allowed for the estimation of pharmacokinetic pk and pharmacodynamic pd parameters from increasingly complex pk. The semimechanistic pk pd model presented in this study was developed in a sequential manner.
With microsoft powerpoint for android youll be able to create bold presentations quickly, start presentations quickly, and deliver an experience that will leave your audience with a lasting impression. The pk pd modeling process includes the following steps. Ln229wildtype epidermal growth factor receptor or ln229egfrviii mutant a sensitizing mutation tumors were administered gefitinib at oral doses of. To rotate the needle of speedometer, a small vba code has been written in the change event of worksheet.
However, if youre reinstalling office, and youve already redeemed a product key and have an account associated with office, then go to the section sign in and install office on your pc or mac. Pharmacokineticpharmacodynamic pkpd indices of antibiotics predicted by a semimechanistic pkpd model. Timedependent pharmacokinetics of dexamethasone and its. Introduction to pharmacology, simplified pk, pd handout for lecture 1, updated 2014. Applications of software packages in pharmacokinetics. Using a stepwise design, pk pd modeling was used to select the dose levels in this study.
Antibiotic stewardship program pk pd approach slideshare. This is the genuine microsoft powerpoint app for android phones and tablets. Using apkpure app to upgrade pk xd, fast, free and save your internet data. Download and install or reinstall office 2016 or office. It is an easytouse tool designed for recovering the lost or. Lumpedparameter pk pd model population pharmacokinetic and pharmacodynamic modeling the lumped element model also called lumped parameter model, or lumpedcomponent model simplifies the description of the behaviour of spatially distributed physical systems into a topology consisting of discrete entities that approximate the behaviour. Semimechanistic pharmacokineticpharmacodynamic modeling. Pharmacokinetic and pharmacodynamic modeling slideshare.
Why pkpd approach is an attractive alternative to the dosetitration to determine a dosage regimen. Microsoft powerpoint 20 is a program that allows you to create professional like presentations. Share them with others and work together at the same time. To our knowledge, this is the first integrated approach providing a mechanistic and quantitative understanding of the pk pd relationship of a cellcycle inhibitor targeting the g 1 restriction point.
The powerpoint app gives you access to the familiar tool you already know. Certaras phoenix platform is the leading pk pd modeling and simulation software used worldwide by 6,000 researchers at biopharmaceutical companies, academic institutions, and global regulatory agencies, including eleven divisions of. Pharmacokineticpharmacodynamic pkpd indices of antibiotics. More speci cally pk focuses on modelling how the drug passes through the body, normally by modelling concentrations in various areas of the body as a function of time, see figure 1a. Epidermal growth factor receptor egfr inhibitors, such as gefitinib, are examples of targeted anticancer drugs whose drug sensitivity is related to gene mutations that adds a pharmacogenetic pg dimension to any pharmacokinetic pk and pharmacodynamic pd analysis. Connect and play with your friends in a safe environment for free. The term pharmacokinetics pk is relatively young and was first introduced in 1953 wagner 1981. The images or slides advance automatically to keep.
Since the slides in this template are animated, you get the utility to reveal each part of your pdca cycle with the help of animated slides that reveal each part of the cycle on mouse. Microsoft office powerpoint microsoft powerpoint 2010 gives you more ways to create and share. Modeling and simulation beyond pkpd powerpoint ppt presentation. The views and opinions expressed in the following powerpoint.
Towards definitive criteria powerpoint ppt presentation. Population pk pd of warfarinpca prothrombin complex activity, the pd parameter, pca0 is pca in the absence ofwarfarin, kd is the degradation rate constant of pca, cgamma,s is the swarfarin conc. Moreover, a semimechanismbased pk pd model was developed, in which the autoinduction effect of dex on its metabolizing enzyme cyp3a was integrated and drug potency was described using an emax. If this is the first time youre installing office you may have some setup steps to do first. Extrapolation of efficacy in the pediatric population. Extrapolation of efficacy in the pediatric population dianne murphy, md, faap. Applications of the pharmacokineticpharmacodynamic pkpd. Preclinical pharmacokineticpharmacodynamic models of. Powerpoint appearance, a sense and the quality of the office and have an experienced, multitouch screen, intuitive that for phones and tablets android has been designed to provide you appreciated.
Download free winner powerpoint templates and slide backgrounds that can be used to make winning presentations. Slideshows and presentations, fast, free and save your internet data. Pirana s research tools nurture a connected, efficient. Quickly create, edit, view, present, or share presentations quickly and easily from anywhere. The goal of this investigation was to cast the combined pg pk pd variables into models that could be. Puff cloud, dance mat, lava lamp, wallpapers, fluffy rug, gamer chair. Bolger, usc school of pharmacy is a windows based multimedia pharmacokinetic pk simulation program that can be used for development and presentation of. This application is for work during the move is designed. Freely distributed java based pk software packageuser friendly pk and graphical software with built in physiologically based pharmacokinetic, deconvolution, noncompartment pk and much more. Collaborate for free with an online version of microsoft powerpoint. Pk data for supporting pk pd analyses essential pk data. The goals of this investigation were to illustrate the use of pharmacokinetic pk pharmacodynamic pd modeling strategies in drug development based on a multipledose study of gefitinib in a preclinical tumor model. A wellcharacterized pk pd model is an important tool in guiding the design of future experiments and trials.
Microsoft makes working on the go with its powerful skydrive. It interfaces with stateoftheart population pk pd modeling tools for visual predictive checks, covariate modeling, and bootstraps. This presentation gives an comprehensive overview about role of pk pd in. Pk xd explore the universe and play with friends apps. Petes powerpoint station is your destination for free powerpoint presentations for kids and teachers about, and so much more. We have been writing software together since our fellowship days at stanford university in the early 1990s.
Download counts were reset to zero on 1 january 2016. Pkquest free pharmacokinetic textbook and software package. Ppt modeling and simulation beyond pkpd powerpoint. Need to access your most recently used powerpoint files. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an. The program provides pharmacokinetic researchers with a fast and easytouse tool for routine and basic pk and pd data analysis with a more userfriendly interface. These are free templates are absolutely free to download and you can use them anywhere. Just as the pk of a drug has been described via mathematical models such as a one or twocompartmental model, the relationship between drug concentration and effect can also be described using mathematical models. Create or view powerpoint presentations with this uptodate version of the popular software package. Pd aims at linking these modelled drug concentration to certain measure of e ect through a pd model. Furthermore, pk pd modeling results were used to help select doses to be used in future siltuximab clinical development. Worried about multiple file versions when you work on. Pecha kucha is a simple presentation format devised by astrid klein and mark dytham where you show 20 slides or images, each for only 20 second.
Role of pk pd in antibiotic stewardship program with case study. In addition, our development team can provide a range of fitforpurpose services to meet specific company requirements. The presentation gives you a bird eyes view regarding basics of pkpd modeling, its applications, types, limitations and various softwares. Pk and pd profiles of the drug are influenced by physicochemical properties of the drug, productformulation, administration route, patients intrinsic and extrinsic. Observed clinical response crossspecies pk pd model predictions vs. Schematic illustration of the full semimechanistic pkpd model describing the time course of the drug. Download latest version of microsoft powerpoint app. Pd relationship from mice well extrapolates to humans. Fileplanet microsoft powerpoint 2016 free download. Pk and pd properties of antisense oligonucleotides. Introduction to pharmacokinetics and pharmacodynamics. Microsoft office powerpoint free version download for pc. Simulations showed that 6 mgkg siltuximab every 2 weeks or 9 mgkg every 3 weeks would reduce serum crp to below 4 mgl.
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